Joachim Herz Selected Research

Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)

1/2018	Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity.
1/2018	Low-density lipoprotein receptor-related protein-1 dysfunction synergizes with dietary cholesterol to accelerate steatohepatitis progression.
10/2016	Expression of a recombinant full-length LRP1B receptor in human non-small cell lung cancer cells confirms the postulated growth-suppressing function of this large LDL receptor family member.
5/2016	Low-Density Lipoprotein Receptor-Related Protein-1 Protects Against Hepatic Insulin Resistance and Hepatic Steatosis.
3/2016	ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice.
4/2010	Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo.
9/2009	LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation.
10/2002	Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning.

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Joachim Herz Research Topics

Disease

29	Alzheimer Disease (Alzheimer's Disease) 01/2024 - 10/2002
13	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 10/2002
12	Atherosclerosis 01/2022 - 04/2003
11	Frontotemporal Dementia (Semantic Dementia) 01/2024 - 02/2010
11	Neoplasms (Cancer) 01/2019 - 10/2004
6	Inflammation (Inflammations) 09/2022 - 01/2012
6	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 09/2017 - 06/2012
5	Insulin Resistance 01/2018 - 11/2007
4	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 01/2021 - 01/2011
4	Cognitive Dysfunction 01/2019 - 10/2002
4	Lung Neoplasms (Lung Cancer) 10/2016 - 06/2004
4	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 11/2014 - 02/2010
3	Thrombosis (Thrombus) 10/2018 - 01/2011
3	Obesity 01/2018 - 11/2007
3	Cardiovascular Diseases (Cardiovascular Disease) 03/2016 - 09/2014
3	Dementia (Dementias) 01/2016 - 06/2010
3	Neointima 10/2014 - 11/2009
3	Hyperlipoproteinemia Type III (Broad Beta Disease) 01/2007 - 08/2003
2	Amyloid Plaque 10/2021 - 01/2019
2	Hypertrophy 01/2021 - 10/2014
2	Body Weight (Weight, Body) 01/2018 - 11/2007
2	Type 2 Diabetes Mellitus (MODY) 01/2018 - 05/2003
2	Fibrosis (Cirrhosis) 01/2018 - 05/2007
2	Hypercholesterolemia 06/2017 - 01/2007
2	Confusion (Bewilderment) 01/2017 - 03/2014
2	Memory Disorders (Memory Loss) 11/2016 - 01/2016
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/2016 - 04/2010
2	Muscle Weakness 06/2015 - 02/2003
2	Neuroinflammatory Diseases 05/2013 - 03/2012
2	Marfan Syndrome (Marfan's Syndrome) 09/2009 - 05/2007
2	Protein Deficiency 05/2004 - 05/2003
1	Autoimmune Diseases (Autoimmune Disease) 03/2024
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 03/2024
1	COVID-19 01/2023
1	Hypertension (High Blood Pressure) 02/2022
1	Encephalomyelitis (Myeloencephalitis) 01/2021
1	Multiple Sclerosis 01/2021
1	Pre-Eclampsia (Preeclampsia) 01/2021
1	Treatment-Resistant Depressive Disorder 01/2021
1	Myocardial Infarction 12/2020
1	Hearing Loss (Hearing Impairment) 01/2020
1	Pulmonary Arterial Hypertension 01/2019

Drug/Important Bio-Agent (IBA)

18	Apolipoproteins E (ApoE)IBA 10/2021 - 10/2002
18	Proteins (Proteins, Gene)FDA Link 01/2018 - 12/2005
15	LDL Receptors (LDL Receptor)IBA 02/2022 - 05/2003
13	CholesterolIBA 01/2022 - 04/2003
13	Amyloid (Amyloid Fibrils)IBA 10/2021 - 10/2007
10	Apolipoprotein E4IBA 01/2024 - 06/2010
10	ProgranulinsIBA 01/2024 - 05/2011
9	ApolipoproteinsIBA 01/2016 - 03/2004
8	Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)IBA 01/2018 - 10/2002
7	LipidsIBA 01/2018 - 03/2004
6	LigandsIBA 01/2017 - 10/2002
5	low density lipoprotein receptor-related protein 8IBA 01/2021 - 09/2014
4	Lipoproteins (Lipoprotein)IBA 02/2022 - 05/2003
4	Antiphospholipid AntibodiesIBA 10/2018 - 01/2011
4	Glycoproteins (Glycoprotein)IBA 10/2018 - 01/2011
4	LDL Lipoproteins (beta Lipoproteins)IBA 01/2018 - 04/2010
4	Lipoprotein Receptors (Lipoprotein Receptor)IBA 01/2017 - 11/2010
4	Protein Isoforms (Isoforms)IBA 11/2016 - 11/2006
3	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 01/2023 - 03/2016
2	reelin receptorIBA 06/2023 - 01/2023
2	Mechanistic Target of Rapamycin Complex 1IBA 01/2022 - 01/2018
2	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2021 - 01/2021
2	Histone Deacetylase InhibitorsIBA 01/2019 - 07/2017
2	Peptides (Polypeptides)IBA 01/2019 - 11/2010
2	Biomarkers (Surrogate Marker)IBA 01/2019 - 01/2017
2	Phosphotransferases (Kinase)IBA 01/2018 - 03/2005
2	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 11/2007
2	Insulin ReceptorIBA 06/2017 - 05/2016
2	Scavenger Receptors (Scavenger Receptor)IBA 01/2017 - 03/2014
2	Apolipoprotein E3IBA 01/2016 - 09/2014
2	ErbB Receptors (EGF Receptor)IBA 12/2014 - 03/2005
2	RNA-Binding Proteins (RNA-Binding Protein)IBA 11/2014 - 09/2014
2	DNA (Deoxyribonucleic Acid)IBA 09/2014 - 03/2005
2	DNA-Binding Proteins (DNA Binding Protein)IBA 03/2011 - 01/2011
2	Transforming Growth Factor beta (TGF-beta)IBA 09/2009 - 05/2007
2	Carrier Proteins (Binding Protein)IBA 11/2006 - 03/2004
1	AntibodiesIBA 03/2024
1	ChemokinesIBA 01/2023
1	Interleukin-4 (Interleukin 4)IBA 01/2023
1	CytokinesIBA 01/2023
1	Blood Proteins (Serum Proteins)IBA 09/2022
1	SterolsIBA 01/2022
1	Antidepressive Agents (Antidepressants)IBA 01/2021
1	Natalizumab (Tysabri)FDA Link 01/2021
1	Monoclonal AntibodiesIBA 01/2021
1	Ketamine FDA LinkGeneric 01/2021
1	Neuropeptide YIBA 01/2021
1	ParvalbuminsIBA 01/2021
1	N-Methylaspartate (NMDA)IBA 01/2021
1	AMPA Receptors (AMPA Receptor)IBA 01/2021
1	Protein Phosphatase 2 (Protein Phosphatase 2A)IBA 01/2021
1	Calbindin 2IBA 01/2021
1	CollagenIBA 12/2020
1	Sodium-Hydrogen ExchangersIBA 01/2020
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2020
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2019
1	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 01/2019

Therapy/Procedure

5	Therapeutics 03/2024 - 06/2004